This study aims to look at how the brain, spinal cord, and breathing muscles work together in people with Down syndrome to better understand the causes of breathing difficulties and identify new ways to improve respiratory health in those with Down syndrome.
Who can participate in this study?
Individuals with Down syndrome ages 10 to 35 years old
Who cannot participate in this study?
- Individuals with a history of neurological injuries, seizures or neurological or psychiatric disorders
- Participants who are unable to follow commands and instructions due to autism or significant intellectual impairment
- Participants that are hemodynamically unstable or have significant medical conditions that could interfere with study procedures
- This includes conditions such as neuropathic pain, depression, mood disorders or significant cognitive impairments that make it difficult to follow instructions during testing
- Individuals with skin breakdown in areas that can potentially contact stimulating electrodes or magnetic coils
- Any pressure injuries that prevent participation in physical activities will be excluded
Where does this study take place?
Thomas Jefferson University, Philadelphia, PA
What activities are involved in this study?
- Two hours of breathing tests
- An MRI
- All completed in two visits
What language does this study support?
English
Is compensation provided?
Yes
If you are interested in participating or have any questions about the Respiratory Neural Drive in Down syndrome Study, please visit the study website or contact the study team at Nairlab@Jefferson.edu.
IRB ID: iRISID-2024-1322