Adult (18+)

Human Trisome Project

Three HTP participants smiling and showing off their blood draw bandages
This project will significantly increase the speed of Down syndrome research and the understanding of associated medical conditions such as leukemia and Alzheimer's disease.
Principal investigator
Joaquín Espinosa, PhD
Location
Denver, CO
Age range
6 months to 89 years old

Clinical Study for Skin and Scalp Diseases in Individuals with Down Syndrome

Woman with alopecia and a person's arm with eczema
This study is testing whether a medicine called abrocitinib can help people 12 years and older with Down syndrome treat alopecia areata (hairloss) and symptoms of atopic dermatitis (eczema).
Principal investigator
Emma Guttman, MD, PhD and Dusan Bogunovic, PhD
Location
New York, NY
Age range
12 years and older

Understanding Differences in Thinking, Learning, and Behavior for Individuals with Down Syndrome With and Without Childhood Cancer

Child with Down syndrome smiling and sitting at the table with her family
The goal of this study is to learn about differences in thinking, learning, and behavior for individuals with Down syndrome with and without a history of childhood cancer; we are recruiting parents and caregivers of individuals with Down syndrome and no history of childhood cancer for this part of the study.
Principal investigator
Lisa Jacola, PhD, ABPP-CN Neuropsychologist, Associate Faculty Member
Location
Virtual
Age range
All ages

Improving Memory in Teens and Young Adults with Down Syndrome

Mother and daughter with Down syndrome using a phone
This is a VIRTUAL 3-month intervention study of the effects of a smartphone application (HippoCamera) on personal event memory in teens and young adults with Down syndrome.
Principal investigator
Jaclyn H. Ford, PhD
Location
Virtual
Age range
15 to 25 years old

Speech, Language and Swallowing in Individuals with Down Syndrome

Individual with Down syndrome sitting at table with other adult, pointing to a chart
This study aims to teach us how to improve services for individuals with Down syndrome who find it hard to be understood through speech and/or experience regular problems with choking on food or liquid. We also seek to understand how the brain helps to control swallowing and speech production.
Principal investigator
Krista Wilkinson
Location
University Park, PA
Age range
18 to 40 years old

Alzheimer's Disease Down Syndrome Study for Future Clinical Trials

Young woman with Down syndrome laughing with a group of friends
The Trial-Ready Cohort-Down Syndrome (TRC-DS) routinely monitors study participants, between the ages of 25-55, for any changes to their brain health or function over time through blood tests and brain imaging to eventually match them with applicable Alzheimer's disease clinical trials.
Principal investigator
Multiple principal investigators
Location
Multiple locations in the United States
Age range
25 to 55 years old
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