The Alzheimer’s Clinical Trials Consortium-Down Syndrome
(ACTC-DS) invites you to participate in the Trial-Ready Cohort- Down Syndrome(TRC-DS). TRC-DS is a community of potential clinical trial volunteers who could help find a cure for Alzheimer’s disease. TRC-DS routinely monitors study participants for any changes to their brain health or function over time through blood tests and brain imaging to eventually match them with applicable AD clinical trials. Because participants are routinely evaluated, researchers can fast-track them for enrollment into qualifying clinical trials as soon as they are eligible. This study is in partnership with the Alzheimer’s Biomarkers Consortium – Down Syndrome(ABC-DS).
The purpose of TRC-DS is to enroll healthy adults with DS across 15 international sites to determine longitudinal cognitive, clinical and biomarker trajectories in the persons with DS and to accelerate enrollment into clinical trials. People with DS helped researchers discover the genetic connection between chromosome 21, amyloid and AD almost 40 years ago. Now, researchers want to bring the latest therapies to people with DS. Recent studies indicate that as many as 8 in 10 people with DS develop AD.
Researchers are looking for people who meet the following criteria:
- Diagnosis of Down syndrome
- Interested in participating in future clinical trials to prevent AD in DS
- Male or female, aged 35-55 years
- In good general health; with no diagnosis of dementia
- Adequate visual and auditory acuity to allow neuropsychological testing
- IQ greater than 40
- Must speak English or Spanish fluently (for select sites only)
- Must have a reliable Study Partner (may be caregiver, sibling, parent) who can provide correct information about the participant’s clinical symptoms and history
Study locations:
Site Name
City
US State/ Country
Postal Code
Status
Site Primary Contact
Washington University in St. Louis School of Medicine
St. Louis
MO
63110
Coming Soon
University of Kentucky: Sanders-Brown Center on Aging & Kentucky Neuroscience Institute
Lexington
KY
40536
Coming Soon
University of Pittsburgh
Pittsburgh
PA
15203
Coming Soon
Indiana University
Indianapolis
IN
46202
Recruiting
Katherine Britt
317-963-7427
brittk@iu.edu
Case Western Reserve University
Beachwood
OH
44122
Coming Soon
University of Wisconsin - Madison, Waisman Center
Madison
WI
53705
Coming Soon
Barrow Neurological Institute
Phoenix
AZ
85013
Coming Soon
Vanderbilt University Medical Center
Nashville
TN
37212
Recruiting
Amy Boegel
615-875-0955
amy.r.boegel@vumc.org
Harvard Medical School, Massachusetts General Hospital
Charlestown
MA
2129
Coming Soon
University of California, Irvine
Orange
CA
92868
Coming Soon
Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
Aurora
CO
80045
Coming Soon
NYS Institute for Basic Research/Columbia University Irving Medical Center
Staten Island
NY
10314
Coming Soon
St. Pau Medical Research Institute
Barcelona
Spain
8041
Coming Soon
King's College London
London
England
SE5 8AF
Coming Soon
University of Cambridge, UK
Cambridge
England
CB2 0QQ
Coming Soon
Note: We will update site contact information as sites are approved to enroll.
For more information about TRC-DS, please visit the website at [https://www.trcds.org]